HBV感染者人类白细胞Ⅰ, Ⅱ类抗原等位基因多态性分析
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张淑云, 李 迪, 谷鸿喜, 李兴库, 金 茜,
乙型肝炎病毒(HBV);HBV感染;人类白细胞抗原(HLA)等位基因;PCR-SSP张淑云,李迪,谷鸿喜,李兴库,金茜,刘伟,杜博,卢滨.乙型肝炎病毒感染者人类白细胞Ⅰ,Ⅱ类抗原等位基因多态性分析.&
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张淑云, 李迪, 谷鸿喜, 哈尔滨医科大学微生物学教研室 黑龙江省哈尔滨市 150086
张淑云, 李兴库, 金茜, 刘伟, 杜博, 卢滨, 哈尔滨医科大学附属第二医院科研实验中心 黑龙江省哈尔滨市 150086
张淑云, 1993年哈尔滨医科大学硕士, 副主任医师, 副教授, 哈尔滨医科大学2003级博士生. 主要从事临床分子病毒学研究和临床基因诊断工作.
黑龙江省自然科学基金资助项目, No. D0307
黑龙江省卫生厅课题基金资助项目, 2005-311
通讯作者: 谷鸿喜, 150086, 哈尔滨市南岗区保健路157号, 哈尔滨医科大学微生物学教研室.hxgu2432@163.com
电话: 传真: 0451-86685122
收稿日期: 2006-02-17 接受日期: 2006-03-07
Analysis of the polymorphism of human leukocyte antigen (HLA) class and class alleles in HBV infection
Shu-Yun ZHANG, Di LI, Hong-Xi GU, Xing-Ku LI, Xi JIN, Wei LIU, Bo DU, Bin LU
Shu-Yun ZHANG, Di LI, Hong-Xi GU, Department of Microbiology, Harbin Medical University, Harbin 150086, China
Shu-Yun ZHANG, Xing-Ku LI, Xi JIN, Wei LIU, Bo DU, Bin LU, The research center of the second affiliated hospital of Harbin Medical University, Harbin 150086, China
Supported by the Natural Science Foundation of Heilongjiang Province, No.D0307; Foundation of Health Department of Heilongjiang Province, 2005-311
Correspondence to: Hong-Xi Gu, Department of Microbiology, Harbin Medical University, Harbin 150086, Heilongjiang Province, China. hxgu2432@163.com
Received: 2006-02-17 Accepted: 2006-03-07
Abstract
AIM: To test the polymorphism of human leukocyte antigen (HLA) class and class alleles in HBV infection.
METHODS: The polymeric chain reaction/sequence specific primer (PCR-SSP) technique was used to determine HLA-A, B, DR B1 alleles in 61 patients with chronic hepatitis B (CHB), 30 recovered people from HBV infection and 40 healthy people ready to donate their bone marrow in Heilongjiang.
RESULTS: The allele frequencies of HLA-DRB1*12 in the chronic hepatitis B group were markedly higher than that in the normal group and the recovered group(0.230 vs 0.075, P = 0.004, OR = 3.674, 95%CI = 1.445-9.338 and 0.230 vs 0.063, P = 0.004, OR = 4 ......
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