[摘要]目的 探讨线粒体毒素3.硝基丙酸(3.nitropropionic acid，3.NPA)预处理对大鼠缺血.再灌注脑损伤的保护作用。 方法 大鼠腹腔注射3.NPA(20mg·kg-1 )3d后制作大脑中动脉缺血.再灌注模型，采用红四氮唑(TTC)染色、荧光法和干湿重法观察3.NPA预处理对缺血2h再灌注24h和48h脑梗死体积、血脑屏障通透性和脑组织含水量的影响。 结果 缺血2h再灌注24h和48h，3.NPA预处理组脑梗死体积变小，血脑屏障通透性降低，脑组织含水量减少，与对照组比较有显著性差异(均P<0.05)。 结论 3.NPA预处理可以诱导脑缺血耐受，降低血脑屏障通透性、减轻脑水肿可能是其机制之一。

    [关键词] 3.硝基丙酸;脑缺血;血脑屏障;脑水肿;大鼠

    The effect of3.nitropropionic acid preconditioning on cerebral ischemia-reperfusion in rats

    DUAN Dong-xiao，ZHU Hong-can，SUN Sheng-gang，LI Hong-ge，XIAO Wei-zhong，TONG E-tang

    (Department of Physiology，Medical Colloge of Zhengzhou University，Zhengzhou450052，China;Department of Neurology，Union Hospital，Tongji Medical College of Huazhong University of Science and Technology，Wuhan430022，China)

    Abstract:Objective To investigate the effect of3.nitropropionic acid preconditioning on cerebral ischemia-reperfusion in rats.Methods Rats were administrated either vehicle or3.NPA at the dose of20mg·kg-1 ，intrap-eritoneal，3days prior to a2h middle cerebral artery occlusion followed by24h or48h of reperfusion.Infarct vol-umes were assessed by a2 ......