子宫颈癌_____子宫颈癌；微卫星不稳定性

D3S1289、D5S406、D6S277微卫星不稳定性与子宫颈癌的相关性

http://www.100md.com 《包头医学院学报》 2006年第1期

子宫颈癌,,子宫颈癌；微卫星不稳定性,1材料与方法,2结果,3讨论,参考文献

     摘要目的: 探讨微卫星不稳定性(microsatellite instability, MI)与子宫颈癌的相关性。方法:22例子宫颈浸润性鳞癌石蜡标本，选取3、5和6号染色体上的3个微卫星位点D3S1289、D5S406、D6S277进行MI分析。结果:在子宫颈癌标本中3个位点均未发现MI和杂合性缺失(LOH)的改变。结论:3个微卫星位点未见MI和LOH的改变，可能与病例少、位点少、种族及取样有关。

    关键词子宫颈癌；微卫星不稳定性

    A Study of Microsatellite Instability in Cervical Cancer

    SHI Shuxian,GENG Li

    (The First Hospital of Baotou Medical College,Baotou 014010,China)

    Abstract Objective:To investigate microsatellite instability (MI) in cervical cancer. Methods: MI of 3 microsatellite markers were detected in 22 invasive squamous cancers and self normal cervix.Results: MI and loss of heterozygosity(LOH) were not detected in D3S1289 ......

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