[摘要] 目的: 探讨建立大鼠脊髓减压病模型的加减压方案。 方法: SD大鼠随机分为正常对照组、安全减压组和快速减压组，快速减压组分别采用3种加减压方案建立大鼠减压病模型，取脊髓胸腰段，HE染色后观察病理变化。 结果: 采用方案Ⅱ(经30s空气加压至1MPa，高压下停留5.5min，50s减至常压出舱)制备的大鼠减压病模型，大体解剖可见所有大鼠脊髓有较多淤血和出血点，病理切片显示广泛的脊髓损伤。 结论: 方案Ⅱ制备的减压病模型大鼠死亡率低而且普遍发生脊髓损伤，可以作为建立脊髓减压病模型的加减压方案之一。

    [关键词] 脊髓减压病;模型;加减压;方案

    Trial to establish a rat model of spinal cord decompression sickness

    ZHAO Min，YIN Ming，ZHANG Jian-cheng，et al

    (Naval Medical Research Institute，Shanghai200433，China)

    Abstract:Objective:To explore decompression profile for developing the rat model of spinal cord decompression sickness.Meth-ods:SD rats were randomly divided into3groups:the control group;the safe decompression group;and the rapid decompression group.In the latter group，decompression sickness models were developed by using3different compression and decompression profiles respectively.Then，a thoracolumbar section of the spinal cord was taken and the observation of the pathological changes made by hematoxylin eosin stain.Results:Gross anatomy revealed that stasis of blood and hemorrhagic spots could clearly be seen in the rat DSC model developed by using profile II(i.e.the animals were compressed with air to1MPa within30s ......