【摘要】 目的 本文研究天然香豆素化合物蛇床子素对多种瘤谱的抗肿瘤活性；并通过对胸腺、脾等多项指标综合考察蛇床子素的高抑瘤活性和低毒性特征。方法 选择小鼠宫颈癌(U14)、肉瘤(S180)、肝癌(H22 )3种瘤株分别接种于昆明种小鼠，给予灌服蛇床子素。结果 3种瘤谱使用蛇床子素均有明显的抑瘤效果，最佳抑瘤率分别为U14 60.0%、 S180 68.2%， H22 62.1% ，并且蛇床子素对小鼠的肝、脾指数和胸腺指数几乎无影响；而阳性对照药顺铂组对小鼠的肝、脾指数、胸腺指数有着明显的损伤。结论 蛇床子素有可能研制成为一种低毒、高效的抗肿瘤新药。

    【关键词】 蛇床子素；宫颈癌U14；肉瘤S180；肝癌H22；抗肿瘤

    Study on the tumor inhibitory effect of osthole

    SHEN Xiu，ZHOU Ze-wei，LIU Pei-xun，et al.

    Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300192,China

    【Abstract】 Objective This paper carries on anti-tumor activities research of the natural coumarin compound osthole to many tumors; and overall tested high-activity and low toxicity traits of osthole by the items of thymus gland, spleen, etc. Methods The mice cervical cancer (U14), sarcoma (S180) and liver cancer (H22) were selected and implanted in Kun Ming mice, and osthole was administered by P.O. way. Results Osthole has obvious anti-tumor activities to the three tumors ......