Relationship between the level of PAIª²1 and extent of coronary lesions in CHD patients accompanied with hyperinsulinmia

    FAN Quan, GUO Wenª²Yi, JIA Guoª²Liang, WANG Haiª²Chang, LI Fei, QIN Tao, LI Weiª²Jie

    Department of Cardiovasology, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To explore the relationship between the level of plasminogen activator inhibitorª²1 (PAIª²1) and the extent of coronary lesions in coronary heart disease (CHD) patients accompanied with hyperinsulinmia. METHODS: Ninetyª²seven CHD patients were included in the study: simple CHD group (32), CHD accompanied with impaired glucose tolerance (IGT) group (31) and CHD accompanied with type 2 diabetes mellitus (T2DM) group (34). The levels of serum insulin and plasma PAIª²1 of all the patients were analyzed by radio immunoassay and chromogenic assay, respectively. All the patients also had coronary angiography and the extent of coronary lesions was analyzed by total amount integral method. RESULTS: The levels of serum insulin, plasma PAIª²1 and coronary artery narrow degree in CHD accompanied with T2DM group were significantly higher than those of simple CHD group and CHD accompanied with IGT group, and those of CHD accompanied with IGT group were significantly higher than those of simple CHD group(P<0.05). Correlation analysis showed that the levels of PAIª²1 and insulin were positively correlated with the coronary artery narrow degree in CHD patients accompanied with hyperinsulinmia. CONCLUSION: Abnormal activity of fibrinoytic system occurs in CHD patients accompanied with hyperinsulinmia. The levels of PAIª²1 and insulin are positively correlated with coronary artery narrow degree in CHD patients accompanied with hyperinsulinmia. ......