前列腺癌Survivin和p53蛋白表达的相关性
Survivin蛋白,,Survivin蛋白;p53蛋白;,前列腺癌;,免疫组化,0引言,1对象和方法,2结果,3讨论
Relationship and expression of survivin and p53 in prostatic carcinomaZHANG Jian,WANG He,QIN WeiJun,ZHANG Geng,YANG XiaoJian,ZHANG Bo,SONG Bin,ZHOU Yu,ZHANG ShiRui,YAN HongLiang
Department of Urology, Xijing Hospital, Fourth Military Medical University, Xian 710033, China
【Abstract】 AIM: To investigate the expression of surviving and p53 in the tissues of prostatic carcinoma and to evaluate the relationship between survivin and p53. METHODS: The expression of survivin and p53 in 55 patients with prostatic carcinoma were examined using immunohistochemical method. RESULTS: The positive cases of survivin and p53 in prostatic carcinoma were 43 (78.18%) and 27 (49.09%), respectively. The positive rate of survivin and p53 was strongly associated with pathological grades and clinical stages (P<0.05). The expression of survivin was correlated with p53 (r=0.629). CONCLUSION: The inhibition of apoptosis caused by the cooperation of surviving and loss of p53 may play a pivotal role in tumorigenneis and tumor progression in prostatic carcinoma. ......
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