成纤维细胞_____血小板衍生生长因子AB;

PDGFAB对人正常皮肤和增生性瘢痕成纤维细胞胶原网收缩影响的差异

http://www.100md.com 《第四军医大学学报》 2005年第3期

成纤维细胞,,血小板衍生生长因子AB;,成纤维细胞;胶原;瘢痕,0引言,1材料和方法,2结果,3讨论

     Effect of PDGFAB on contraction of human normal skin and hypertrophic scar fibroblastpopulated collagen lattice

    DONG MaoLong, CHEN Bi, XU MingDa, HU DaHai, HAN JunTao, YAO QingJun

    Department of Burn Surgery, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To study the effect of PDGFAB on the contraction of human normal skin and hypertrophic scar fibroblastpopulated collagen lattice and to investigate the mechanism by which PDGFAB promotes wound healing and the effect of PDGFAB in scar forming. METHODS: In vitro cultured human normal skin and hypertrophic scar fibroblasts (NsFb, HTsFb) were applied to measure the effect of PDGFAB on the contraction of FPLC. RESULTS: PDGFAB increased the contraction of NsFb and HTsFbpopulated collagen lattice in a dose dependent manner, but it had stronger effects on HTsFbpopulated collagen lattice. CONCLUSION: PDGFAB may promote wound healing by stimulating the wound contraction, and PDGFAB may also play some important roles in scar contracture. ......

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