【摘要】 目的 探讨危重症人群血清胆碱酯酶(ChE)水平与APACHE Ⅱ评分的关系。方法 对116例收入EICU 24h内的危重患者的血清胆碱酯酶水平进行测定，并测定30例正常人的血清胆碱酯酶水平对照分析,比较两组间的差异。同时对这116例患者进行APACHEⅡ评分,按照APACHEⅡ评分分值的高低分成3组(<15分组、15～20分组、>20分组),比较不同组别间血清胆碱酯酶水平的差异。将本组116例危重症患者按照是否死亡分为死亡组和存活组,比较两组间血清胆碱酯酶水平的差异。结果 (1) 危重症患者的血清胆碱酯酶平均水平较正常人明显降低(P<0.01)。(2)危重症患者的血清胆碱酯酶水平与其APACHEⅡ评分的分值成负相关(r=-0.2251，P<0.01),病情越危重, APACHEII评分分值越高，死亡率越高,相应血清胆碱酯酶水平越低下(P<0.01)。结论 血清胆碱酯酶水平是反映危重症病情及评价预后的一项重要参考指标。

    【关键词】 危重症患者；血清胆碱酯酶；APACHE Ⅱ；评分

    The relationships between serum cholinesterase measurement of critical care patients and acute physiological and chronic health evaluationⅡ

    WANG Chen, ZHU Yu-qing,ZENG Qing,et al.

    Emergency Department ,China-Japan Friendship Hospital, Beijing 10029,China.

    【Abstract】 Objective To study the relationships between serum cholinesterase measurement of critical care patients and acute physiological and chronic health evaluationⅡ. Methods The levels of serum cholinesterase in 116 critical care patients and 30 normal people were detected with colorimetric method to find their difference. A severity of illness score (APACHE Ⅱ) was determined for each patient during the first 24 h in the EICU , at the same time, serum cholinesterase were measured. First, these patients were divided into three groups based on their different scores and then were divided into two groups based on their prognosis: survival group and death group. Results (1) The serum cholinesterase levels in critical care patients were markedly lower than those in normal people (P<0.01).(2) The serum cholinesterase levels in critical care patients were reverse correlated with APACHEⅡscore(r=-0.2251,P<0.01).Conclusion The serum cholinesterase level might be an important index reflecting the critical care patient’s condition, and an index for estimation of the prognosis. ......