Expression of substance P in intestinal tissue of rats and the relation between substance P and mucosa permeability in acute necrotizing pancreatitis

    SU Shi-zhi，SHI Xin，GAO Nai-rong

    (1.Department of General Surgery，Daxing Hospital，Bejing102600，China;

    2.Department of General Surgery，Zhongda Hospital，Southeast University，Nanjing210009，China)

    Abstract:Objective To investigate the expression of substance P in rats'intestinal tissue and study the relation be-tween substance P and mucosa permeability in acute necrotizing pancreatitis(ANP).Methods 80adult Sprague-Dawley rats were randomly divided into control group(n=40)and ANP group(n=40).Sacrifices were made in8，12，16and20h later in every group after ANP model was established by injecting5%sodium taurocholate into pancreatic duct respectively.The in-testinal mucosal permeability and the expression of substance P were studied.Results In ANP groups，intestinal mucosal per-meability and the expression of substance P were significantly higher than those in the control group(P<0.05).The overex-pression of substance P was correlated with the intestinal mucosal permeability in ANP(r=0.66 ......