氯沙坦_____氯沙坦；高血压；高尿酸血症；左室功能

氯沙坦对高血压合并高尿酸血症患者血尿酸代谢和左室功能的影响

http://www.100md.com 《中华现代内科学杂志》 2006年第4期

氯沙坦,,氯沙坦；高血压；高尿酸血症；左室功能,1资料与方法,2结果,3讨论

     【摘要】目的观察并分析氯沙坦对轻、中度原发性高血压合并高尿酸血症患者血尿酸代谢和左室功能的影响，并与非洛地平比较。方法 72例轻、中度原发性高血压合并高尿酸血症患者随机、单盲分为2组，治疗组36例，用氯沙坦50mg,po,qd；对照组36例，用非洛地平5mg,po,qd；2组用药4周末如坐位舒张压≥12kPa或收缩压≥18.7kPa者剂量加倍，疗程均为8周。结果 8周末降压总有效率治疗组为81%，对照组为75%，2组间比较，P>0.05。血尿酸水平在8周末治疗组下降(-126±38)μmol/L(P<0.01)，对照组下降(-25±32)μmol/L(P>0.05)，2组间比较，P<0.01。左室功能指标在8周末治疗组IVST、LVPWT、LVMI明显降低(P<0.01)，LVEF明显升高(P<0.01)，IVST、LVPWT、LVMI、LVEF2组间比较，P<0.05。结论氯沙坦不仅能有效降压，而且能降低血尿酸水平，改善左室功能。

    【关键词】氯沙坦；高血压；高尿酸血症；左室功能

    Effects of losartan on serum uric acid metabolism and LV function of patients with essential hypertension complicated by hyperuricemia

    JIA Min,YANG Jie. Department of Internal Medicine,Hospital of South China University of Technology,Guangzhou,510640 China

    【Abstract】 Objective To observe and analyze the effects of losartan on serum uric acid metabolism and LV function of patients with mild to moderate essential hypertension complicatedby with hyperuricemia,which is also compared with felodipine.Methods Seventytwo patients with mild to moderate essential hypertension complicatedby hyperuricemia were randomly divided into treatment group (n=36) and control group (n=36).Patients of the treat group received losartan 50mg,po,qd for 4wk and those of the control group received felodipine 5mg,po,qd for 4wk,then,followed by dose doubling for another 4wk in those patients with seated diastolic blood pressure≥12kPa or systolic blood pressure≥18.7kPa.Results At the end of 8wk treatment,the total effective rates of decompression was 81% for the treatment group and 75% for the control group,respectively.There was no significant diffierence in curative effect between the two groups,P>0.05.Compared with pretreatment,the serum uric acid level was descented (-126±38)μmom/L in the treatment group and (-25±32)μmom/L in the control group.The total effective rates were 72% and 11%,respectively.There was significant difference between the two groups,P<0.01.After 8 wk treatment,the IVST,LVPWT and LVMI of LV function descented while LVEF of LV function ascended apparently (P<0.01).There was significant difference between two groups in IVST,LVPWT,LVMI and LVEF of LV function (P<0.01).Conclusion Losartan can not only reduce blood pressure but also decrese serum uric acid level and improve LV function. ......

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