Application of multidrug resistance of bladder tumor cell in the treatment of invasive bladder tumor

    WU Xiao-peng，LU Shu-yan，CAI Lei-ming，ZOU Jian-gang，ZHOU Zhong-xing， GUAN Nai-fu，CHEN Yang-zhi，CHEN Jing

    (Department of Urology，the Second Hospital of Changzhou，Nanjing Medical University，Changzhou213003，China)

    Abstract:Objective To detect multidrug resistance in bladder tumor，thus to select sensitive drugs to treat invasive bladder tumor.Method In10cases of bladder tumors，P-gp，GST-p and TopoⅡwere detected by immunohistochemistry technique before intra-arterial chemotherapy.Results Before intra-arterial chemotherapy the expression rate of P-gp was30%，GST-p was10%，TopoⅡwas50%.Chemotherapy drug were THP，DDP and HCPT.After intra-arterial chemothera-py，the expression rate of P-gp was50%，GST-p was20%，TopoⅡwas40%，respectively.Conclusion Detection of P-gp，GST-p and TopoⅡplay a role in selection of drug in invasive bladder tumor.

    Key words:bladder tumor;multidrug resistance;immunohistochemistry;chemotherapy

    [摘要]目的: 探讨过氧化物还原酶1(Prx1)表达增加对人肿瘤细胞抗过氧化氢毒性作用的影响。 方法: 构建Prx1真核表达质粒 ......