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老年肺癌患者外周血单个核细胞hTERT基因表达
http://www.100md.com 《第四军医大学学报》 2006年第6期
肺肿瘤,,老年人;肺肿瘤;人端粒酶反转录酶;基因表达,0引言,1对象和方法,2结果,3讨论,【参考文献】
     Expression of human telomerase reverse transcriptase gene in peripheral blood mononuclear cells of lung cancer in elderly patients

    HE Ping, WANG HongFeng

    Cadre Ward, Second Affiliate Hospital, China Medical University, Shenyang 110004, China

    【Abstract】 AIM: To investigate the significance of the expression levels of human telomerase reverse transcriptase (hTERT) gene in peripheral blood mononuclear cells of lung cancer in elderly patients. METHODS: The expression levels of hTERT were detected in 20 elderly patients with lung cancer and 10 normal elderly subjects by quantitative measurement with RTPCR. RESULTS: The expression levels of hTERT mRNA in the lung cancer patients (0.927±0.115) were significantly higher than those in normal subjects (0.408±0.124, P<0.001), without significant correlation with pathological types and clinical stages. CONCLUSION: The quantitative measurement with RTPCR for the expression levels of hTERT mRNA is an effective method in the diagnosis of lung cancer in patients who are not fit for other examinations. ......

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