Effect of continuously infused propofol of different concentrations on serum lipid metabolism in rabbits

    ZHOU Liª²Hua, XU Liª²Xian, ZHANG Hui, LI Yuan, XU Ruiª²Fen, WANG Huiª²Xia£¬LIU Chunª²Ran

    Department of Anesthesiology, College of Stomatology, Fourth Military Medical University, Xi¬ðan 710033£¬China

    ¡¾Abstract¡¿ AIM: To observe the pharmacodynamics of 50 g/L propofol and its effect on the serum lipid metabolism of rabbits. METHODS: Twelve rabbits of both sexes were randomized into 2 groups. All rabbits received 6 mg/kg bolus doses at a speed of 0.6 mg/s of 10 g/L and 50 g/L propofol from a marginal ear vein, the effect onset time was recorded. Propofol was then administered under computer control for 360 min at a speed of 400 ¦Ìg/(kg¡¤min) . The heart rate, blood pressure and respiration rate were measured during the infusion, and the recovery time was recorded. Arterial blood samples were collected before infusion and 5, 30, 60, 180, 360 and 365 min after infusion for the measurement of blood propofol concentrations and the serum concentrations of triglyceride, cholesterol, highª²density lipoprotein cholesterol and lowª²density lipoprotein cholesterol. RESULTS: The effect onset time and the blood propofol concentrations at different time points had no statistical difference (P>0.05). In the 10 g/L propofol group, compared with preª²infusion, the serum triglyceride levels were significantly increased 60, 180 and 360 min after infusion (P<0.01), and the serum cholesterol concentration was also elevated 360 min after infusion (P<0.01). In the 50 g/L propofol group, the serum triglyceride level was statistically higher only after 360 min infusion (P<0.01) than that before infusion, but was significantly decreased when compared with that of the 10 g/L propofol group at the same time. There was no significant difference in the recovery time between the 2 groups (P>0.05). CONCLUSION: 50 g/L propofol has the pharmacodynamic effect similar to that of 10 g/L propofol, but the former can delay the occurrence of serum lipid metabolism. ......