A serologic study on Helicobacter pylori infection and infertility

    DU Jiuª²Wei, XU Keª²Yi, TAO Xinª²Rong, ZHU Fuª²Xi, CHEN Tianª²Yi, REN Hongª²Yan

    Department of Reproductive Medicine, School of Medicine, Anhui University of Science & Technology, Huainan 232001, China

    ¡¾Abstract¡¿AIM: To study the relationship between Helicobacter pylori infection and infertility. METHODS: Serum H.pyloriª²IgG, antisperm antibody (AsAb), T lymphocyte subsets and some cytokines were detected in 125 patients (male 58, femal 67) with infertility. RESULTS: The positive rates of H.pyloriª²IgG and AsAb in patients with infertility were 46.4% and 21.6%, which were higher than those in normal control group (P<0.01). The positive rates of AsAb in patients with H.pyloriª²IgGª²positive or ª²negative infertility patients were 32.8% and 11.9%, with a significant difference between them (P<0.01). In H.pyloriª²IgGª²positive infertility patients, the CD3+, CD4+ and CD4+/CD8+ decreased, the serum ILª²4, ILª²6, IFNª²¦Ã and TNF increased, and the ratios of IFNª²¦Ã to ILª²4 decreased (P<0.05). CONCLUSION: H.pylori is an infertilityª²causing pathogen. The increased positive rates of AsAb and cytokines may be involved in the development of infertility. ......