盐酸乙哌立松治疗血管性帕金森病肌张力增高的疗效初探
盐酸乙哌立松,,盐酸乙哌立松；血管性帕金森病；肌张力过强；治疗,1资料与方法,2结果,3讨论,【参考文献】
【摘要】 目的 观察盐酸乙哌立松治疗血管性帕金森病(vascular Parkinsonism，VP)肌张力增高的临床疗效及副作用。方法 采用开放性治疗前后自身对照方法，给予诊断为VP的25例患者服用盐酸乙哌立松50mg,2次/d，疗程4周。比较服药前、服药后第2周和第4周时肌张力Ashworth评分和Barthel指数评分。结果 第2周和第4周时VP患者Ashworth评分明显改善，总有效率分别为58.3%和62.5%,差异有显著性 (P<0.05),Barthel指数与服药前比较有轻度好转，但差异无显著性。结论 盐酸乙哌立松可以改善VP患者的肌张力，是否能提高患者的日常生活能力尚有待进一步研究。【关键词】 盐酸乙哌立松；血管性帕金森病；肌张力过强；治疗
Preliminary study on effects of eperisone in treatment of hypermyotonia following vascular Parkinsonism
WANG Ge-ying，JIANG Lin，CHEN Yu-hui.Department of Neurology,Tongji Hospital Affiliated to Tongji University,Shanghai 200065,China
【Abstract】 Objective To observe the clinical effect of eperisone in treatment of hypermyotonia following vascular Parkinsonism (VP) and the side effect.Methods An openlabel selfcontrol study of eperisone were done in the 25 cases of hypemryotonia followingVP.The patients were given 50mg eperisone,two times every day,continuously for 4 weeks.Comparative analysis was made in the scoring of Ashworth and grading of Brunstrum 2 and 4 weeks after treatment.Results A remarkable improvement of Ashworth scoring in muscular tension was found at 2 and 4 weeks after treatment.The total effective rate was 58.3% and 62.5%,respectively.There showed statistical difference (P<0.05).Comparing before administration,Barthel grading had slightly improved but there was no significant difference (P>0.05).Conclusion Eperisone can improve hypermyotonia,whether eperisone can promote the daily life ability of VP patients should be study further. ......
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