64例上皮性卵巢癌的临床及预后分析
上皮性卵巢癌,,上皮性卵巢癌；临床分期；手术；化疗；预后,1资料与方法,2结果,3讨论,参考文献：
摘要：目的：探讨影响上皮性卵巢癌预后的因素。方法：对64例卵巢上皮性癌的病例资料进行回顾性分析,26例早期(Ⅰ~Ⅱ)病人以全子宫切除加双附件切除为主，38例晚期(Ⅲ级及以上)以肿瘤减灭术为主，术后化疗以CAP方案为主(环磷酰胺、阿霉素、顺氯氨铂)。结果: 早期患者存活率明显高于晚期患者(P<0.01)。38例晚期患者中，理想的肿瘤减灭术 (无残灶或残灶<2 cm) 者存活率明显高于不理想的肿瘤减灭术 ﹙残灶≥2 cm)者(P<0.05)。术后化疗次数≥6次者与<6次者存活率差异有统计学意义(P<0.05)。分化程度对预后有明显影响(P<0.05)，但年龄及病理类型对预后影响差异无统计学意义(P>0.05)。肿瘤的临床分期、残灶大小及化疗次数对预后影响较大。结论：早期诊断、首次手术彻底以及化疗疗程≥6次是改善上皮性卵巢癌预后的关键。关键词：上皮性卵巢癌；临床分期；手术；化疗；预后
The clinical and prognostic analysis of 64 cases with epithelial ovarian cancer
Anaguli·Ababaikeli， Gulina·Ababaikeli, Xukerhan·Saidi
(Department of Gynecology, First Affiliated Hospital, Xinjiang Medical University,Urumqi 830054, China)
Abstract: Objective: To investigate the prognostic factors of epithelial ovarian carcinoma. Methods: The clinical data and followup data of 64 patients with epithelial ovarian carcinoma who were treated in our hospital between Feb 1995 to Feb 2005 were retrospectively studied. Results: The median survival of 64 patients with epithelial ovarian carcinoma was 26 months. The survival rate of patients in early stage (FIGO stage Ⅰ and Ⅱ) was significantly higher than that of patients in advanced stage (FIGO stage Ⅲ) (P<0.01). All patients received surgical therapy. Among advanced stage of patients, good cytoreductive surgery (no residue or residue<2 cm) were performed in 20 patients and their survival rate was significantly higher than these of 18 unsuccessful cases(residue≥2 cm ), 26 patients undertook 6 or more courses of chemotherapy their survival rate was also significantly higher than that of 38 patients who undertook less than 6 courses. The survival rate of patients with different pathological grade had significant difference (P<0.05). Clinical stage, size of residue and the courses of chemotherapy were independent prognostic factors. Conclusion: Early diagnosis, primary optimal cytoreductive surgery and 6 or more courses of chemotheraphy might improve the survival of patients with epithelial ovarian carcinoma. ......
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