Effect of 8 Hz/90 dB infrasound on rat cardiac cell apoptosis and its underlying mechanism

    YAO Xiaoª²Yi, PEI Zhaoª²Hui, ZHU Miaoª²Zhang, CHEN Jingª²Zao

    1Department of Geriatrics, First Clinical Hospital, Haerbin Medical University, Haerbin 150086, China, 2Deparment of Physiology, School of Basic Medicine, 3Infrasound Lab of Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To observe the changes of cardiac cell apoptosis in rats exposed to infrasound with 8 Hz of 90 dB for different time periods and to study its underlying mechanism. METHODS: The rats were exposed to infrasound with 8 Hz /90 dB 2 h daily for 1, 7, 14, 21 and 28 d and then the cardiac cell apoptosis and the [Ca2+] change in cardiac cells were measured. RESULTS: Cardiac cell apoptosis rate increased as time went on (P<0.01) and [Ca2+] in cardiac cells significantly increased as time went by(P<0.01). CONCLUSION: The 90 dB infrasound can induce the cardiac cell apoptosis. These changes are positively associated with the infrasound exposure time. ......