转移特性不同的大肠癌细胞形貌结构的差异分析
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余 力, 刘 莉, 张艳菲, 蔡颍谦, 李祖国,
原子力显微镜;结直肠癌;细胞系;形态结构;转移余力,刘莉,张艳菲,蔡颍谦,李祖国,丁彦青.转移特性不同的大肠癌细胞形貌结构的差异分析. 世界华人消化杂志2006;14(11)1097-11
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余力, 南方医科大学珠江医院病理科 广东省广州市 510282
刘莉, 张艳菲, 李祖国, 丁彦青, 南方医科大学病理学教研室 广东省广州市 510515
蔡颍谦, 南方医科大学珠江医院神经外科 广东省广州市 510282国家自然科学基金资助项目, No. 30370649
通讯作者: 丁彦青, 510515, 广东省广州市, 南方医科大学病理学教研室.
电话: 020-61642148 传真: 020-61642148
收稿日期: 2006-02-12 接受日期: 2006-03-03
Distinction analysis for variance of morphological architecture and different property of metastasis in human colorectal carcinoma cells
Li Yu, Li Liu, Yan-Fei Zhang, Ying-Qian Cai, Zu-Guo Li, Yan-Qing Ding
Li Yu, Department of Pathology, Zhujian Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China
Li Liu, Yan-Fei Zhang, Zu-Guo Li, Yan-Qing Ding, Department of Pathology, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Ying-Qian Cai, Department of Neurosurgery, Zhujian Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China
Supported by National Natural Science Foundation of China, No. 30370649
Correspondence to: Dr. Yan-Qing Ding, Department of Pathology, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Received: 2006-02-12 Accepted: 2006-03-03
AbstractAIM: To investigate the correlation between the different property of metastasis and the variance of morphological architecture in human colorectal carcinoma (HCC) cell lines.
METHODS: The morphological architectures of three HCC cell lines with the identical genetic background and different property of metastasis, including SW620 (lymphatic metastasis), SW480 (hematogenous and lymphangitic metastasis) and SW480/M (hepatic metastasis), were observed by light microscopy and atomic force microscopy (AFM), and the expression of carcinoembryonic antigen (CEA), CD44v5, Fascin and proliferating cell nuclear antigen (PCNA) in those cell lines were detected by immunohistochemical method ......
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