应用SELDI-TOF-MS技术分析SEB染毒小鼠血清蛋白质组学变化
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张靖, 张军, 应天翼, 高川, 宋云扬, 王惠芳
SELDI-TOF-MS;蛋白质芯片;SEB;标志蛋白张靖,张军,应天翼,高川,宋云扬,王惠芳.应用SELDI-TOF-MS技术分析SEB染毒小鼠血清蛋白质组学变化. 世界华人消化杂志20
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张靖, 张军, 应天翼, 高川, 宋云扬, 王惠芳, 防化研究院第四研究所 北京市 102205
通讯作者: 王惠芳, 102205, 北京市, 防化研究院第四研究所. bjzhangjing@tom.com
电话: 01066758323
收稿日期: 2006-03-10 接受日期: 2006-03-24
Application of SELDI-TOF-MS technology in detection of serum proteomic changes of mice exposed to staphylococcal enterotoxin B
Jing Zhang, Jun Zhang, Tian-Yi Ying, Chuan Gao, Yun-Yang Song, Hui-Fang Wang
Jing Zhang, Hui-Fang Wang, Jun Zhang, Tian-Yi Ying, Chuan Gao, Yun-Yang Song, Research Institute of Chemical Defense, Beijing 102205, China
Correspondence to: Hui-Fang Wang, Research Institute of Chemical Defense, Beijing 102205, China.bjzhangjing@tom.com
Received: 2006-03-10 Accepted: 2006-03-24
AbstractAIM: To study the changes of serum proteome in mice exposed to staphylococcal enterotoxin B (SEB).
METHODS: The serum proteins in mice exposed to SEB were detected by surfaced enhanced laser desorption/ionization time of flight mass spectroscopy (SELDI-TOF-MS) and weak cation exchange proteinchip. The data were read with PBSII-C type proteinchip reader and analyzed with Biomarker Wizard and Biomarker Patterns Software of Ciphergen Company.
RESULTS: In comparison with the control group, there were significant deviations of 11 proteins in the test group. Among them, 8 proteins were up-regulated and 3 down-regulated ......
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