三七__(中国医学)

三七总皂苷对肝纤维化小鼠血清中转化生长因子β1 及白介素1的影响

http://www.100md.com 《时珍国医国药》 2006年第1期

三七,,三七总皂苷；肝纤维化；转化生长因子β1；白介素1；小鼠,三七总皂苷对肝纤维化小鼠血清中转化生长因子β1及白介素1的影响,2方法,3结果,参考文献：

     摘要：目的观察三七总皂苷对肝纤维化小鼠血清中TGFβ1及IL1的影响，探讨三七总皂苷抗肝纤维化可能的免疫学机理。方法用CCl4复制小鼠中毒性肝纤维化模型，同时给与三七总皂苷治疗，酶联免疫吸附实验(ELISA法)测定血清中TGFβ1及IL1的水平，并行肝脏病理组织切片检测。结果三七总皂苷能显著降低肝纤维化小鼠血清中TGFβl及IL1的水平，减轻肝纤维化程度。结论三七总皂苷具有抗肝纤维化作用，其机理可能与降低血清中TGβp1及IL1的水平有关。

    关键词：三七总皂苷；肝纤维化；转化生长因子β1；白介素1；小鼠

    Effects of Panax notoginseng Saponins on TGFβ1 and IL1 in Mice Serum with Liver Fibrosis

    YU Wangui, ZHANG Hengwen, HE Shangrong, YAN Nianchun

    (College of Medical Science，Yangtze University,Jingzhou, Hubei 434000,China)

    Abstract:Objective To observe effects of Panax notoginseng saponins(PNS)on TGFβ1 and IL1 of serum in mice with 1iver fibrosis.MethodsThe model of CCl4 induced liver fibrosis was established in mice and they were treated with PNS.Serum 1evel of TGFβ1 and IL1 were determined and observed tissue patho1ogy.ResultsIt significantly decreased 1evel of TGFβ1 and IL1 in serum with PNS treatment ......

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