【摘 要】 目的 探讨了支气管哮喘患儿血内皮素和一氧化氮含量的变化。 方法 应用放免法和化学法测定了38例支气管哮喘患儿血内皮素和一氧化氮含量、并与35名正常健康人作比较。 结果 支气管哮喘患儿血内皮素水平明显升高(P<0.01)。一氧化氮水平明显下降(P<0.01)且与患儿病情程度有关。 结论 支气管哮喘患儿血管内皮细胞存在内分泌功能的紊乱，ET合成释放增加，一氧化氮释放减少，以及两者反馈调控失衡在支气管哮喘的发病中具有重要意义。

    【关键词】 支气管哮喘;内皮素;一氧化氮;儿童

    The clinical significance of determination of plasma endothelin and nitric oxide in patients with bronchial asthma SHENG Hong.(Lianyungang First People's Hospital，Jiangsu222002，China)

    【Abstract】 Objective To explore the changes of plasma endothelin and nitric oxide in patients with bronchial asthma.Methods The concentrations of plasma endothelin(ET)and nitric oxide were detected in38patients by radioimmunoassay and chemistry and35normal controls were compared.Results The plasma ET levels in patients with bronchial asthma were significantly high-er than those in normal controls(P<0.01)while plasma NO levels were decreased markedly(P<0.01).The score index of bronchial asthma had significant correlation with the levels of plasma ET and NO.Conclusion The functional changes of vessel endothelial cells in patients with bronchial asthms and the imblance of endothelial relaxing and contracting factors might play an important part in the pathogenesis of bronchial asthma. ......