摘要 :癌症恶病质是晚期肿瘤患者的常见综合征，它主要由于蛋白质、脂肪和糖代谢严重紊乱而导致出现厌食、体重下降、骨骼肌消耗和乏力等恶病质表现。近年来认为其发病机制主要是肿瘤产物和宿主细胞因子(TNF-α、IL-1和IL-6)释放共同作用所致。因此目前针对癌症恶病质的药物治疗主要以促进食欲、抗分解代谢(抗细胞因子)和同化激素类药物为主，以改善患者生活质量和延长生存期。这类药物除了皮质醇激素和孕激素之外，还包括细胞因子拮抗剂、沙立度胺、己酮可可碱、鱼油、褪黑激素、支链氨基酸、中药等。

    关键词 :癌症;恶病质;药物治疗

    Progress in drug treatment of cancer cachexia

    SHI Hui-chang，DU Xiu-ping

    (Xuzhou Medical College，Xuzhou，Jiangsu221002，China)

    Abstract:Cancer cachexia is a common syndrome in advanced cancer patients，which is characterized by profound chang-es in protein，fat and carbohydrate metabolism，resulting in anorexia，weight loss，muscle wasting and poor performance status.In recent years，cachexia has been understood as the result of major metabolic abnormalities due to a combination of host cyto-kine release(TNF-α，IL-1，and IL-6)and tumor products.At present，the pharmacological treatments，including orexi-genic(appetite stimulants)，anti-catabolic(and anti-cytokine)and anabolic agents，all aim to improve the quality of life and extend survival period.Pharmacological treatments，beside that of hydrocortisone and progestogen ......