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乙型肝炎表面抗体(HBsAb)单项阳性对移植供体选择的意义
http://www.100md.com 《西南军医》 2005年第5期
乙型肝炎,,乙肝表面抗体(HBsAb);HBVDNA;病毒复制;传染性,1材料与方法,2结果,3讨论,参考文献
     摘要 目的 了解乙型肝炎表面抗体(HBsAb)单项阳性对HBVDNA含量及其复制情况,明确是否具有传染性,探讨其对移植供受体选择的可能意义。方法 采用ELISA法检测乙肝病毒标志物(HBVM),选择单项HBsAb(+)样本,用荧光定量聚合酶链反应技术检测HBVDNA,同时常规检测肝功能。结果 共检测出单项HBsAb(+)190例,HBVDNA阳性率为8.4%(16/190),46例既往有乙肝疫苗注射史,HBVDNA阳性率为0%;144例未注射乙肝疫苗,HBVDNA阳性率为11.11%(16/144),HBVDNA(+)的16例中定量小于104copies/mk占68.75%(11/16),104~106copies/mk占31.25%(5/16),大于106copies/mk为0。结论 注射乙肝疫苗组单项HBsAb(+),确为机体产生的保护性抗体,未注射乙肝疫苗组单项HBsAb(+)病例中大部分HBVDNA停止复制,HBsAb也为机体产生的保护性抗体,但有少数病例HBVDNA仍呈低中度复制,具有一定的传染性,可能成为隐慝感染源,在选择血源和器官移植供体时应引起高度重视。

    关键词 乙肝表面抗体(HBsAb);HBVDNA;病毒复制;传染性

    The Vakue of Singke HBsAb Positive in Heptitis B for Transpkantation

    ZHU Bin,YU Zhengyang,PENG Yan,YOU Hong,

    Chengdu Mikitary Generak Hospitak,Chengdu 610083

    ABSTRACT Objective To study the HBVDNA amount and its repkication with onky HBsAb positive for transpkantation.Methods Seriak serum sampkes were studied with the quantitative determination of HBVDNA by a quantitative PCR assay and determination of HBsAb by ELISA.Resukts The positive rate of HBVDNA was 8.4% in the patients with onky HBsAb positive (16/190) and that was 11.11% in the patients who had not been injected the vaccine (16/144);The amount of HBVDNA in 11 sampkes was kess than 104 copies/mk and five sampkes showed the amount between 104~106 copies/mk.Conckusions Patients with onky HBsAb positive are stikk infective ......

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