【摘 要】 目的 研究肝内血管病变在乙型肝炎(HB)病程中的表现及意义。 方法 对138例HB患者首、末2次肝活检标本用组织化学(组化)、免疫组织化学(免疫组化)染色及电镜技术进行了观察。 结果 肝血管炎症、破坏、阻塞、增生及肝窦毛细血管化是HB组织学一大特点，其病变可引发肝血供障碍，导致肝细胞变性坏死、纤维化及肝硬变。经治疗多数肝血管病变是可逆的，首、末2次相比差异有显著性(P<0.05)。 结论 在HB的病程中，致病源主要是HBV，有多种蛋白质参与其病理转化。肝内血管病变是影响HB肝组织学后果的关键因素。

    【关键词】 肝炎，乙型;肝内血管病变;肝活检组织

    Dynamic changes of intrahepatic vascular diseases in follow┐up biopsies of hepatitis B SUN Hong-xia，YANG Kai.(Huaibei People's Hospital，Anhui235000，China)

    【Abstract】 Objective To study the manifestation and significance of intrahepatic vascular diseases during hepatitis B(HB).Methods 138cases of patients who had been performed biopsies at least two times were selected，and observed with histochem-istry，immunohistochemistry and electron microscope.Results Intrahepatic vascular inflammory，destruction，obstruction，prolif-eration and hepatic sinusoidal capillarization are important histological characters in HB.The diseases can lead to disorder of hep-atic blood supply，which in turn may result in degeneration and necrosis of hepatocytes，fibrosis and cirrhosis.Many cases of the intrahepatic vascular diseases are reversible after treatment.There is significant difference between the first and the last biopsies(P<0.05).Conclusion During the course of HB ......