脑肿瘤_____]_脑肿瘤_；_药物敏感试验

颅内恶性肿瘤体外化疗敏感试验的临床应用观察

http://www.100md.com 《齐鲁医学杂志》 2006年第1期

脑肿瘤,,],脑肿瘤,；,药物敏感试验,；药物疗法,1材料和方法,2结果,3讨论,[参考文献]

     [摘要] 目的研究颅内肿瘤组织标本体外化疗药物敏感性与临床疗效的关系，为颅内恶性肿瘤病人个体化化疗提供依据。方法将新鲜的41例恶性颅内肿瘤组织标本应用MTT法进行7种脑肿瘤常用化疗药物以及与尼莫通(NIM)联合的体外敏感性测定，经筛选后将敏感药物经静脉或颈内动脉超选择应用。结果 41例颅内恶性肿瘤病理标本对7种化疗药物总体上较为敏感，其单独药物敏感顺序依次为卡氮芥(BCNU)、威猛(VM26)、甲氨喋呤(MTX)、顺铂(DDP)、足叶乙甙(VP16)、长春新碱(VCR)、阿霉素(ADM)，与NIM联合药物的抑制率顺序依次为BCNU、VM26、VP16、DDP、ADM、VCR。药物治疗随访观察，1年以上存活71.9%(23/32)，2年以上存活56.3%(18/32)。结论常规脑肿瘤化疗药物对不同个体敏感程度不一，因此，体外化疗药物敏感试验可帮助临床医生制定合理的化疗方案，按其结果指导化疗可能有助于提高颅内恶性肿瘤病人的远期存活率。

    [关键词] 脑肿瘤；药物敏感试验；药物疗法

    CLINICAL STUDY ON IN VITRO CHEMOTHERAPY SENSITIVITY TEST OF INTRACRANIAL MALIGNANT TUMORS

    WANG HOUZHONG，KONG JUN， GE QIAN， et al

    (Department of Neurosurgery, Qingdao Municipal Hospital, Qingdao 266011,China)

    [ABSTRACT]ObjectiveTo provide a guidance for individual chemotherapy in patients with intracranial malignant tumors by studying the relativity of chemosensitivity of antitumor drugs. MethodsThe chemosensitivity of seven kinds of antitumor drugs and their combination with nimodipine were tested, in vitro, in 41 intracranial malignant tumors by MTT method. Results The seven drugs for the tumors were carmustine, VM26, methotrexate, cisplatin, VP16,vincristin and adriamycin, which associated with nimodipine was carmustine, VM26,VP16, cisplatin, adriamycin, and vincristin. The oneyear survival was 71.9% (23/32), and twoyear survival, 56.3% (18/32). ConclusionThe chemotherapy sensitivity in patients with intracranial malignant tumors is different. Chemotherapy under the guidance of chemosensitivity in vitro may establish reasonable methods and improve longterm survival of patients with intracranial malignant tumors. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/04/25/97/07/06.htm

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