食管癌MMP基因高表达与临床病理特征的关系
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张翠萍, 薛会光, 武 军, 张 琪, 孔心娟
食管癌;基质金属蛋白酶;病理,张翠萍,薛会光,武军,张琪,孔心娟,通讯作者,Relationshipbetweenexpressionofmatrixmet
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张翠萍, 薛会光, 武军, 张琪, 孔心娟, 青岛大学医学院附属医院消化科 山东省青岛市 266003
山东省自然科学基金资助项目, No. 1999CA1CKB3
通讯作者: 张翠萍, 266003, 山东省青岛市江苏路16号, 青岛大学医学院附属医院消化科. jianyilu16@yahoo.com.cn
电话: 0532-82767938
收稿日期: 2005-12-29 接受日期: 2006-03-11
Relationship between expression of matrix metalloproteinase and clinicopathological characteristics in esophageal carcinoma
Cui-Ping Zhang, Hui-Guang Xue, Jun Wu, Qi Zhang, Xin-Juan Kong
Cui-Ping Zhang, Hui-Guang Xue, Jun Wu, Qi Zhang, Xin-Juan Kong, Department of Gastroenterology, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China
Supported by the Natural Science Foundation of Shandong Province, No. 1999CA1CKB3
Correspondence to: Dr Cui-Ping Zhang, Department of Gastroenterology, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China. jianyilu16@yahoo.com.cn
Received: 2005-12-29 Accepted: 2006-03-11
Abstract
AIM: To study the expression of matrix metallo-proteinases (MMP-2, MMP-7, and MMP-9) and their correlations with clinicopathological characteristics in esophageal carcinoma.
METHODS: The expression of MMP-2, MMP-7, and MMP-9 mRNA were detected in 48 cases of esophageal carcinoma and cancer-adjacent tissues by the reverse transcriptase polymerase chain reaction (RT-PCR).
RESULTS: The expression of MMP-2, MMP-7, and MMP-9 were significantly higher in esophageal carcinoma tissues than those in cancer-adjacent ones, respectively (χ2 = 5.978, 19.045, 5.440; P < 0.05-0.001). The expression of MMP was markedly correlated with the tumor size (r = 0.84, 0.70, 0.48; P < 0.05-0.001), degree of differentiation (r = 0.89, 0.57, 0.91; P < 0.05), and clinical staging (r = 0.81, 0.73, 0.61; P < 0.05). MMP-2 expression was also notably correlated with lymph node metastasis (r = 0.048, P < 0 ......
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