介入化疗联合放疗对胃癌肝转移患者免疫调控作用及疗效的影响
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张 强, 朱金水, 姚惠香, 郭跃武, 朱 励
胃癌;介入化疗;放疗,张强,朱金水,姚惠香,朱励,郭跃武,通讯作者,Influenceofinterventionalchemotherapy
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张强, 上海交通大学附属第六人民医院肿瘤放疗科 上海市 200233
朱金水, 姚惠香, 朱励, 上海交通大学附属第六人民医院消化科 上海市 200233
郭跃武, 上海交通大学附属第六人民医院肿瘤内科 上海市 200233
通讯作者: 朱金水, 200233, 上海市宜山路600号, 上海交通大学附属第六人民医院消化科. zhujs1803@hotmail.com
电话: 021-64369181-8969 传真: 021-64837019
收稿日期: 2006-03-07 接受日期: 2006-03-20
Influence of interventional chemotherapy combined with radiotherapy on immunomodulatory mechanism of gastric cancer patients with liver metastasis
Qiang Zhang, Jin-Shui Zhu, Hui-Xiang Yao, Yue-Wu Guo, Li Zhu
Qiang Zhang, Department of Radiotherapy, the Affiliated Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai 200233, China
Jin-Shui Zhu, Hui-Xiang Yao, Li Zhu, Department of Gastroenterology, the Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China
Yue-Wu Guo, Department of Oncology, the Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China
Correspondence to: Department of Gastroenterology, the Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China. zhujs1803@hotmail.com
Received: 2006-03-07 Accepted: 2006-03-20
Abstract
AIM: To explore the immunomodulatory effects and efficacy of liver arterial chemotherapy combined with radiotherapy in the treatment of patients with metastatic hepatocarcinoma from gastric cancer.
METHODS: Thirty-three gastric patients with liver metastasis were divided into 2 groups. Patients in group A were treated with liver arterial chemotherapy in combination with radiotherapy (TD2000-3500cGy) under the guidance of DSA with the regimen of high-dose EAP (VP16 100 mg/m2, adriamycin 60 mg/m2 + carboplatin 200 mg/m2), while patients in group B received single liver arterial chemotherapy. The levels of Detecting the level of interleukin-2 (IL-2), tumor necrosis factor-α (TNF-α), and interferon-g (IFN-g) were detected and the short-term efficacy was analyzed ......
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