乌司他丁对胆石病合并肝硬化手术患者肝功能的保护作用
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高 伟, 张圣林, 秦宪斌, 鲁德忱, 张新明,
乌司他丁;胆石病;肝硬化;肝功能,高伟,张圣林,秦宪斌,鲁德忱,张新明,董建德,通讯作者,Protectiveeffectsofulinastati
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高伟, 张圣林, 秦宪斌, 鲁德忱, 张新明, 董建德, 青岛市海慈医疗集团普外科 山东省青岛市 266033
通讯作者: 高伟, 266033, 山东省青岛市人民路4号, 青岛市海慈医疗集团普外科. phulin@sohu.com
电话: 0532-83777370
收稿日期: 2006-01-03 接受日期: 2006-01-24
Protective effects of ulinastatin on liver function of postoperative patients complicated with cholelithiasis and liver cirrhosis
Wei Gao, Sheng-Lin Zhang, Xian-Bin Qin, De-Chen Lu, Xin-Ming Zhang, Jian-De Dong
Wei Gao, Sheng-Lin Zhang, Xian-Bin Qin, De-Chen Lu, Xin-Ming Zhang, Jian-De Dong, Department of General Surgery, Qingdao Hiser Hospital, Qingdao 266033, Shandong Province, China
Correspondence to: Wei Gao, Department of General Surgery, Qingdao Hiser Hospital, Qingdao 266033, Shandong Province, China. phulin@sohu.com
Received: 2006-01-03 Accepted: 2006-01-24
Abstract
AIM: To investigate the protective effects of ulinastatin on the liver function of postoperative patients complicated with cholelithiasis and liver cirrhosis.
METHODS: Ninety-seven patients complicated with cholelithiasis and liver cirrhosis were divided into control group and therapeutic group. The patients in therapeutic group were intravenously injected with ulinastatin 3 d after operation. The liver function indexes were determined in both groups 1 d before operation and 1, 3, 5 d after operation.
RESULTS: The incidence rates of incisional wound infection, incurable ascites and pulmonary infection in the control group were 19.1%, 12.8% and 14.9%, respectively, while those in the therapeutic group were 6.0%, 4.0% and 6.0%, respectively. The rate of postoperative complication in the therapeutic group was significantly lower than that in the controls (P < 0.05) and correlated with Child’s staging (P < 0.05). The liver function indexes were also obviously superior to that in the controls (P < 0.05).
CONCLUSION: Application of ulinastatin during peripheral operation can protect the liver function and reduce the complication rate in patients complicated with cholelithiasis and liver cirrhosis ......
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