肝癌经肝动脉栓塞化疗后VEGF和CD44v6表达的意义
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李兴睿, 杨志芳, 易继林
肝细胞癌;经肝动脉化疗栓塞术;血管内皮生长因子;CD44v6,李兴睿,杨志芳,易继林,通讯作者,ExpressionofCD44v6andvas
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李兴睿, 杨志芳, 易继林, 华中科技大学同济医学院附属同济医院普外科 湖北省武汉市 430030
通讯作者: 李兴睿, 430030, 湖北省武汉市, 华中科技大学同济医学院附属同济医院普外科. chenwenyyy@163.com
电话: 027-83663818
收稿日期: 2006-02-17 接受日期: 2006-03-15
Expression of CD44v6 and vascular endothelial growth factor in hepatocellular carcinoma after transcatheter hepatic arterial chemoembolization
Xing-Rui Li, Zhi-Fang Yang, Ji-Lin Yi
Xing-Rui Li, Zhi-Fang Yang, Ji-Lin Yi, Department of General Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Correspondence to: Xing-Rui Li, Department of General Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. lixingrui@sina.com
Received: 2006-02-17 Accepted: 2006-03-15
Abstract
AIM: To investigate the role of vascular endothelial growth factor (VEGF) and CD44v6 in the recurrence and metastasis of hepatocellular carcinoma (HCC) after transcatheter hepatic arterial chemoembolization (TACE).
METHODS: The expression of CD44v6 and VEGF in 29 HCC samples obtained from the patients underwent secondary hepatectomy after TACE was examined by immunohistochemical staining and morphometric analysis. HCC samples (n = 30) obtained from the patients without TACE were used as the control group.
RESULTS: The value of VEGF absorbance in the TACE group was 0.149 ± 0.021, significantly higher than that in the controls (0.134 ± 0.018,P < 0.05). The positive rate of CD44v6 expression was 82.8% and 66.7% in the TACE group and control group, respectively, without significant difference between them (P > 0.05). The numbers of CD44v6 positive cells were also not markedly different between the two groups (112.4 ± 22.3 vs 102.4 ± 21.2, P > 0.05).
CONCLUSION: VEGF may take part in the recurrence and metastasis of HCC after TACE, while CD44v6 may not ......
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