盐酸丁咯地尔_

盐酸丁咯地尔对急性脑梗死患者血清IL1β、IL6、TNFα及血液流变学的影响

http://www.100md.com 《疑难病杂志》 2006年第2期

盐酸丁咯地尔,,盐酸丁咯地尔；脑梗死，急性；血液流变学；IL1β；IL6；TNFα；神经功能缺损程度评分,盐酸丁咯地尔对急性脑梗死患者血清IL1β、IL6、TNFα及血液流变学的影响

     【摘要】目的研究盐酸丁咯地尔对急性脑梗死患者血清IL1β、IL6、TNFα水平及血液流变学的影响，探讨盐酸丁咯地尔的神经保护机制。方法对60例经头部CT或MRI确诊的急性脑梗死患者进行随机配对后分为丁咯地尔治疗组和常规治疗组各30例。分别采集患者就诊时及治疗后第1 d、2 d、7 d外周血样本检测IL1β、IL6及TNFα水平，以及就诊时及治疗15 d后外周血样本血液黏度、血浆黏度、血小板聚集率及纤维蛋白原水平，同时对患者治疗前及治疗后第3 d、7 d、15 d进行神经功能缺损程度评分。结果丁咯地尔治疗组治疗后第2 d、7 d血IL1β及IL6水平较常规治疗组有明显降低(P<0.01)；第1 d、2 d血TNFα水平较常规治疗组有明显降低(P<0.01)；治疗15 d后血液黏度、血小板聚集率较常规治疗组有明显降低(P<0.05)。治疗第3 d、7 d及15 d神经功能缺损程度评分较常规治疗组有显著改善(P<0.01)。结论盐酸丁咯地尔注射液可明显降低急性脑梗死患者血IL1β、IL6及TNFα的水平及血液流变学各项指标，且能改善神经功能。

    【关键词】盐酸丁咯地尔；脑梗死，急性；血液流变学；IL1β；IL6；TNFα；神经功能缺损程度评分

    The effects of buflomedil hydrochloride on the levels of IL1β,IL6,TNFα and hemorrheology in patients with acute cerebral infarction

    LIU Yafang，ZHANG Junjian，WANG Youguang.

    Department of Neurology，Huangshi Central Hospital, Hubei，Huangshi 435000，China

    【Abstract】 Objective To investigate the effects of buflomedil hydrochloride on hemerrheology and the levels of IL1β,IL6 and TNFα in patients with acute cerebral infarction,and to explore the mechanism of buflomedil hydrochloride in protecting nervous system.Methods 60 patients with acute cerebral infarction diagnosed by CT or MRI were chosen and randomly divided into buflomedil hydrochloride treatment group and routine treatment group.Each group had 30 patients. Blood samples were collected to detect the levels of IL1β,IL6 and TNFα at the time when patients visited a doctor for the first time and at the 1st,2nd and 7th day after treatment. At the same time the blood samples were colleted to detect the levels of blood viscosity, plasma viscosity,platelet aggregation rate and fibrinogen when patients firstly visited a doctor and after they had been treated for 15 days.Results The levels of IL1β and IL6 in buflomedil hydrochloride treatment group were obviously lower than those in routine treatment group at the 2nd and 7th day (P<0.01).The levels of TNFα were decreased significantly at the 1st and 2nd day in buflomedil hydrochloride treatment group (P<0.01).The blood viscosity and platelet aggregation rate in buflomedil hydrochloride treat ment group were obviously decreased at the 15th day,as compared with that of routine treatment group (P<0.05).There was a significant difference in the defect scoring of nervous function at the 3rd,7th,15th day after treatment between the two groups (P<0.01).Conclusion Buflomedil hydrochloride injection can decrease obviously the parameters of hemorrheology and the levels of IL1β,IL6 and TNFα in the patients with acute cerebral infarction,which could improve the nervous function. ......

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