Effect on indexes of liver fibrosis by combined use of Lamivudine and Coussein in treating chronic hepatitis B

    Xu Qingª²Jie

    Department of Traditional Chinese Medicine,Huaihe Hospital,Henan University,Kaifeng 475000£¬China

    ¡¾Abstract¡¿ AIM: To explore the effect on the physiological indexes of liver fibrosis by combined use of Lamivudine and coussein in treating chronic hepatitis B. METHODS: Sixtyª²four chronic hepatitis B patients were randomly divided into 2 groups: 33 in the treatment group and 31 in the control group. The 2 groups received the same basic treatment. The treatment group was given intravenous drip of coussein 600 mg/d during the first three months,followed by oral taking of coussein capsule,0ª±2 g,3 times per day for one year. The control group was given compound shell liver softening tablets orally,2 g/d for one year.RESULTS: After one year of treatment, ALT turned normal (100%),HBeAg became negative (60.6%),HBV DNA became negative (96.9%) in the treatment group,all significantly higher than those in the control group (80ª±6%,9ª±7% and 3ª±2% respectively) (P<0.01). The indexes of serum fibrosis (Ha LN,PC¢ó and ¢ôª²C) in the treatment group were markedly different from those in the control group(P<0.01).CONCLUSION: Combined use of coussein and Lamivudine is effective in treating chronic hepatitis B and preventing liver fibrosis. As the liver functions become normal, and HBeAg and HBVDAV turn negative, the indexes of fibrosis quickly drop. ......