白藜_____]_血管;白藜芦醇;鸡胚绒毛尿囊膜

白藜芦醇与半边旗二萜类化合物5F对活体血管生成的影响

http://www.100md.com 《实用医技杂志》 2006年第1期

白藜,,],血管;白藜芦醇;鸡胚绒毛尿囊膜,1材料与方法,3讨论,参考文献：

     [摘要] 目的：观察白藜芦醇(Res)、半边旗二萜类化合物5F(以下简称5F)对活体血管生成的影响。方法：采用鸡胚绒毛尿囊膜(CAM)试验，检测Res和5F对活体血管生成的影响。结果：与对照组相比，Res用药组(11.4 μg/egg、45.7 μg/egg)的血管生成抑制率分别为(32.2±3.6)%、(53.7±4.2)%，5F用药组(8.3μg/egg、33.2 μg/egg)血管生成抑制率分别为(19.7±4.0)%、(36.5±3.0)%。结论：Res和5F可抑制活体血管生成，对肿瘤和其他病理情况下的抗血管治疗可能具有重要应用价值。

    [关键词] 血管;白藜芦醇;鸡胚绒毛尿囊膜

    Effect of Resveratrol and the Diterperoid Compound 5F Isolated from Pteris Semipinnata L on Angiogenesis in Vivo

    HE Zhenhui1, HE Taiping1, MO Lier2，LIANG Nianci1

    (1.Guangdong Medical College，Zhanjiang,Guangdong 524023,China；2.Guangdong Natural Drug Research and the Development Point Laboratory Zhanjiang,Guangdong 524023,China)

    Abstract：Objective To investigate the effect of resveratrol and the diterperoid compound 5F isolated from Pteris semipinnata L on angiogenesis in vivo.Methods The chicken chorioallantoic membrane (CAM) assay was used to detect the effect of resveratrol and compound 5F on angiogenesis in vivo. Results The inhibitory rates of Res on angiogenesis of CAM were(32.2±3.6)%、(53.7±4.2)% with the dose of 11.4 μg/egg、45.7 μg/egg;the inhibitory rates of 5F on angiogenesis of CAM were(19.7±4.0)%、(36.5±3.0)% with the dose of 8.3 μg/egg、33.2 μg/egg.Conclusion Res and 5F can inhibit blood vessel formation in CAM,which implies their application in treatment on angiogenesis in tumor or other pathological conditions. ......

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