心肌梗死__(期刊论文)

汉族群体血管紧张素原基因T174M多态性与心肌梗死相关

http://www.100md.com 《第四军医大学学报》 2005年第8期

心肌梗死,,心肌梗死；血管紧张素原；基因；聚合酶链反应；限制性片段长度多态性,1材料和方法,2结果,3讨论,【参考文献】

     Polymorphism of angiotensinogen gene is associated with myocardial infarction in Chinese Han population

    ZHANG AnPing1,NING ShuCheng1,LI ZhanQing2,YI Xue2

    1Department of Cell Biology,School of Biology,2Department of Cardiovasology,Affiliated Hospital,Coal Medical College of North China,Tangshan 063000,China

    【Abstract】 AIM: To study the association of a molecular variant of angiotensinogen AGT (T174M) gene with myocardial infarct (MI) in Chinese Han population.METHODS: AGT (T174M) allele was determined by polymerase chain reactionrestriction fragment length polymorphism (PCRRFLP).RESULTS: The frequencies of AGT (M174) allele (167%) and 174MM genotype (76%) in the MI group were higher than those in the control group (149% and 945% respectively, χ2=757, P<0025 and χ2=579,P<005),AGT gene 174MM genotype was an significantly increased risk factor of MI (odds ratio 366,P=0.018) .CONCLUSION: AGT (T174M) may be an independent risk factor for MI in Chinese Han population. ......

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