三氧化二砷_____三氧化二砷；乳腺肿瘤；小鼠，裸；基因

As2O3对裸鼠移植人乳癌组织NFκB p65，p53，cMyc和hTERT表达的影响

http://www.100md.com 《第四军医大学学报》 2005年第8期

三氧化二砷,,三氧化二砷；乳腺肿瘤；小鼠，裸；基因,As2O3对裸鼠移植人乳癌组织NFκBp65，p53，cMyc和hTERT表达的影响,1材料和方法,2结果,3讨论,【参考文献】

     Effect of As2O3 on expression of NFκB p65,p53,cMyc and hTERT in heterologous graft model for human breast infiltrating duct carcinoma in nude mice

    MA YinBin,WU ChenYi，CHEN Xin

    Department of General Surgery,First Affiliated Hospital，Chongqing University of Medical Sciences，Chongqing 400016，China

    【Abstract】 AIM: To investigate the effect of As2O3 on the expressions of NFκB p65,p53,cmyc and hTERT protein in heterologous graft model for human breast infiltrating duct carcinoma in nude mice.METHODS: A model of nude mice bearing human breast infiltrating duct carcinoma was set up and divided randomly into four groups.The expressions of NFκB p65,p53,cmyc and hTERT protein were examined in the tissues by immunohistochemistry.RESULTS: The positive expression rates of NFκB p65,p53,cmyc & hTERT protein were high in the negative group of nude mice model.The positive expression of NFκB p65 in experimental group 1 and 2 was gradually descending with the increase dosage of As2O3 (P<001) and showed a remarkable descending tendency compared with that in the negative and male groups (P<001).But the expressions of p53,cmyc and hTERT protein were not different among the four groups (P>005).CONCLUSION: As2O3 inhibits the high expression of NFκB p65 protein in heterologous graft model for human breast infiltrating duct carcinoma in nude mice in a dosedependent manner and As2O3 does not affect the expression of p53,cmyc and hTERT protein.No relationship is found between NFκB p65,p53,cmyc and hTERT. ......

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