创伤_____脑；创伤；海马；Apaf1；凋亡

大鼠脑创伤后海马区Apaf1表达

http://www.100md.com 《第四军医大学学报》 2005年第8期

创伤,,脑；创伤；海马；Apaf1；凋亡,1材料和方法,2结果,3讨论,【参考文献】

     Apaf1 expression in hippocampus after traumatic brain injury in rats

    ZHU Jun,LIU QingJun,YANG Peng,LI JianMin,FU AiJun

    Department of Neurosurgery,Affiliated Hospital，Northern China Coal Medical College,Tangshan 063000,China

    【Abstract】 AIM: To study the mechanism of nerve cell apoptosis after traumatic brain injury (TBI) .METHODS: The model of severe closed traumatic brain injury was used and the expression of Apaf1 in hippocampus was dynamically observed in rats after TBI by means of immunohistochemistry.RESULTS: The expression of Apaf1 was not found in the hippocampus in both sham operation group and normal control group.The expression of p53 protein was found in the area of CA2 in hippocampus at 6 h (A=0.047 0.008) after TBI in rats.The expression reached the peak at 24 h (A=0.182 0.028)and decreased at 48 h.(A=0.121 0.016)CONCLUSION: The increased expression of Apaf 1 may lead to nerve cell apoptosis after TBI.

    【Keywords】 brain;wound;hippocampus;Apaf1;apoptosis

    【摘要】目的：研究颅脑创伤后神经细胞凋亡的机制.方法：采用重型闭合性颅脑创伤大鼠模型.利用免疫组化方法 ......

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