摘要: 弥漫性轴索损伤(diffuse axonal injury，DAI)后，β淀粉样前体蛋白(β-amyloid precursor protein，β-APP)在轴索内积聚，是轴索损伤的一个重要病理标志。许多研究通过β-APP的检测，对轴索损伤的程度进行评估。β-APP在病理状况下分解生成β淀粉样蛋白(amyloid betaprotein，Aβ)，后者具有多方面的神经毒性作用。笔者现对β-APP的结构、功能、代谢和它在DAI后的表达、作用及其机制进行如下综述。

    关键词: β淀粉样前体蛋白;β淀粉样蛋白;弥漫性轴索损伤

    Relationship betweenβ-amyloid precursor protein and diffuse axonal injury

    LIUHong-en，SUN Xiao-chuan

    (Department of Neurosurgery，First Affiliated Hospital，Chongqing University of Medical Sciences，Chongqing 400016，China)

    Abstract: Accumulation ofβ-APP occurs in injured axons after diffuse axonal injury(DAI)，and it is an important pathological marker of DAI.Axonal injury can be evaluated by detection ofβ-APP.Under pathological condition，β-APP is decomposed into amyloid beta-protein(Aβ)，which has varieties of neurotoxic effects.The structure，function and me-tabolism ofβ-APP are briefly introduced，and its expression，effects and mechanism of action after DAI are also reviewed in the paper.

    Key words:β-amyloid precursor protein;amyloid beta-protein;diffuse axonal injury

    DAI是一种重度脑损伤类型，是导致颅脑伤患者死亡、植物生存和严重神经功能障碍的最主要原因 ......