【摘要】 目的 探讨妊娠期肺功能的变化与胎儿宫内发育迟缓(IUGR)的关系。方法 对180例IUGR患者(IUGR组)和120例正常孕妇(对照组)进行肺功能测定和血气分析，比较两组间差异。结果 IUGR组与对照组在肺活量、用力肺活量、第一秒用力呼气量、残气容量方面比较差异有显著性(P<0.05)。IUGR组与对照组在PCO2、HCO-3方面比较差异有显著性(P<0.05)，两组pH值、PO2差异并无显著性(P>0.05)。结论 IUGR组患者存在肺限制性通气障碍及不同程度的呼吸性碱中毒，致胎儿组织慢性缺氧而发育迟缓。

    【关键词】 呼吸功能试验；胎儿发育迟缓

    Research on the association of lung functional change and fetal intrauterine growth retardation

    WAN Bo,FU Si-mao,HUANG Li-qing,et al.Department of Obstetrics and Gynecology,Zhongshan Maternity and Child Care Hospital(Boai Hospital),Zhongshan 528403,China

    【Abstract】 Objective To investigate the relationship between the change of lung function and fetal intrauterine growth retardation(IUGR).Methods Lung function tests and blood-gas analysis were performed in180 cases of fetal intrauterine growth retardation(IUGR group) and 120 normal pregnant women (control group).The difference between the two groups was statistically analyzed.Results The significant difference of two groups was observed with regard to lung capacity,forced vital capacity,and forced expiratory volume in first second,residual volume.The differences of PCO2 and HCO3- in two groups were statistically significant(P<0.05).No significant difference of pH,PO2 was found between normal pregnant women and pregnant patients with fetal intrauterine growth retardation(P>0.05).Conclusion Restrictive ventilatory disorder and respiratory alkalosis of different degree exist in pregnant patients with fetal intrauterine growth retardation caused by chronic hypoxia of fetal tissue. ......