序列多态性_____线粒体DNA；序列多态性；D环区

中国保安族线粒体 DNA D环区遗传多态性的研究

http://www.100md.com 《第四军医大学学报》 2005年第20期

序列多态性,,线粒体DNA；序列多态性；D环区,中国保安族线粒体DNAD环区遗传多态性的研究,1对象和方法,2结果,3讨论,【参考文献】

     Polymorphism of mitochondrial DNA Dloop region in Chinese BAOAN ethnic group

    LIU XinShe, LI ShengBing

    he National Key Laboratory of Forensic Medicine, Ministry of Health, Xian Jiaotong University, Xian 710061, China

    【 Abstract】AIM: To investigate the mitochondrial DNA sequence polymorphism in Chinese BAOAN ethnic group and to provide basic data for ethnic origin investigation and forensic purpose. METHODS: Genomic DNA was extracted from the whole blood of 98 unrelated individuals of Chinese BAOAN ethnic group by standard chelex100 method. The sequence polymorphism was determined by PCR amplification and direct sequencing. RESULTS: Sixtysix polymorphic sites and 62 haplotypes were identified in mtDNA Dloop region (np1609116418) . The genetic diversity was calculated to be 0.9862, and the genetic identity was 0.0237. CONCLUSION: There are some particular polymorphism sites in Chinese BAOAN ethnic group, and these sites provide an important basis to investigation of the origin of BAOAN and the relationship between BAOAN and other ethnic groups. The result also suggests that sequence polymorphism (np1609116418) in human mitochondrial DNA can be an useful tool for forensic identity. ......

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