【摘要】 目的 评价奥沙利铂为主的化疗结合中药治疗直肠癌肝转移的临床疗效、毒副反应及患者生活质量的改善情况。方法 54例无其他部位转移的直肠癌肝转移病人，随机分为治疗组(化疗加中药)和对照组(单纯化疗)，对照组使用奥沙利铂、四氢叶酸(CF)、氟尿苷(5-FUDR)治疗；治疗组除化疗外再结合健脾理气为主的中药。治疗后评价生存率、生活质量变化、毒副反应以及出现其他部位转移的情况。结果 治疗组有效率57.2%，中位生存时间为17.6个月，1、2、3年生存率分别为71.4%、42.3%、12.9%；而对照组有效率38.5%，中位生存时间为13.4个月，1、2、3年生存率分别为67.8%、25.9%、13.3%。生活质量评价量表提示治疗组的生活质量改善情况优于对照组，并且治疗组较少出现其他部位的转移，耐受性良好。结论 以奥沙利铂为主化疗结合健脾理气为主的中药治疗直肠癌肝转移可以获得较好的疗效和生活质量，并且毒副作用较单纯化疗轻。

    【关键词】 奥沙利铂； 化疗； 直肠癌； 肿瘤转移； 中草药

    A clinical trial of chemotherapy combined with oxaliplatin plus Chinese medicine in the treatment of metastatic liver carcinoma of rectal cancer

    GAN Ning,CHEN Huan-chao.

    Department of Ttraditional Chinese Medicine and West Medicine,Hubei Cancer Hospital,Wuhan 430079,China

    【Abstract】 Objective To evaluate the efficacy of chemotherapy combined with oxaliplatin and Chinese medicine in the treatment of metastatic liver cancer of rectal cancer. Methods A totol of 54 patients with metastatic liver cancer of rectal cancer were divided randomly into treated group and control group. Patients of control group was treated by oxaliplatin,5-fluorouracil,and calcium folinate,and patients of treated group by oxaliplatin,5-fluorouracil,calcium folinate and traditional medicine of Jianpiliqi.Results The overall response rate of treat group was 57.2%,median survival time of treat group was 17.6 months,and 1-,2-,3-year survival rate of treat group was 71.4%,42.3%,12.9%. The overall response rate of control group was 38.5%,median survival time of control group was 13.4 months,and 1-,2-,3-year survival rate of control group was 67.8%,25.9%,13.3%.Quality of life of treated group was better than that of control group.Conclusion Combination with oxaliplatin and traditional Chinese medicine of Jianpiliqi is more effctive in the treatment of metastatic liver cancer of rectal cancer than chemotherapy only. ......