关键词：经皮冷冻切除；氩氦刀；软组织肉瘤；断层摄影术，X线计算机

    摘要：目的 探讨经皮氩氦刀治疗软组织肉瘤的临床疗效、CT影像学的变化及不良反应。 方法 32例软组织肉瘤患者在CT定位后，经皮穿刺置入行氩氦刀进行治疗。 结果 经氩氦刀治疗后3个月，胸部、腹部、四肢CT复查显示52个肿瘤病灶明显缩小(CR+PR为73.1%)。CT显示肿瘤冷冻后呈低密度坏死区，3个月冷冻区实变，12个月冷冻区阴影几乎消失。术后并发症包括气胸、咳嗽、咯血、腹痛、反应性胸腔积液、转氨酶升高和发热。 结论 氩氦刀冷冻治疗软组织肉瘤创伤小，效果较好，无严重并发症，是治疗软组织肉瘤的一种新的有效治疗方法。

    Clinical application of CT-guided percutaneous targeted argon-helium cryoablation for soft tissue sarcoma

    SONG Qian¹, ZHAN Ying², LI Lu-jia<sup>1

    1</sup>Department of Oncology, 401 Hospital of PLA; ²Affiliated Hospital of Medical College of Qingdao University, Qingdao 266071, China

    Abstract: Objective To evaluate the clinical curative effect of percutaneous targeted argon-helium cryoablation for soft tissue sarcoma and analyze the changes in CT findings and side effects in relation to the treatment. Methods Thirty-two patients with soft tissue sarcoma were treated with CT-guided argon-helium cryoablation. Results Three months after the treatment, 52 tumors showed obvious reduction in size with a total complete and partial remission rate of 73.1%. Postoperative CT scanning displayed low-density local necrosis in the tumors after cryotherapy, and consolidation of the lesions was observed at 3 months and lesion disappearance at 1 year after the therapy. The complications included pneumothorax, coughing, hemoptysis, fever, and slight elevation of aminotransferase. Conclusion CT guided percutaneous targeted argon-helium cryoablation is safe and effective for lung cancer with minimal invasions. ......