大鼠重症急性胰腺炎内毒素血症、细胞因子和一氧化氮的变化及善宁的治疗作用
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王艳蕾, 张凤宇, 景友玲, 赵景霞, 赵春秀,
胰腺炎;内毒素;肿瘤坏死因子;白细胞介素6;一氧化氮;过氧化脂质;善宁,王艳蕾,景友玲,赵景霞,赵春秀,段国贤,张凤宇,通讯作者
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王艳蕾, 景友玲, 赵景霞, 赵春秀, 段国贤, 华北煤炭医学院生理教研室 河北省唐山市 063000
张凤宇, 唐山市丰润区第一人民医院消化科 河北省唐山市064000
通讯作者: 王艳蕾, 063000, 河北省唐山市建设南路57号, 华北煤炭医学院生理教研室. xiaolei1973@yahoo.com.cn
电话: 0315-3725606
收稿日期: 2006-03-14 接受日期: 2006-03-30
Changes of endotoximia, cytokines and nitric oxide and therapeutic effects of sandostatin in rats with severe acute pancreatitis
Yan-Lei Wang, Feng-Yu Zhang, You-Ling Jing, Jing-Xia Zhao, Chun-Xiu Zhao, Guo-Xian Duan
Yan-Lei Wang, You-Ling Jing, Jing-Xia Zhao, Chun-Xiu Zhao, Guo-Xian Duan, Department of Physiology, North China Coal Medical University, Tangshan 063000, Hebei Province, China
Feng-Yu Zhang, Department of Gastroenterology, the First People’s Hospital of Fengrun District, Tangshan 064000, Hebei Province, China
Correspondence to: Yan-Lei Wang, Department of Physiology, North China Coal Medical University, Tangshan 063000, Hebei Province, China. xiaolei1973@yahoo.com.cn
Received: 2006-03-14 Accepted: 2006-03-30
Abstract
AIM: To study the roles of endotoximia, cytokines and nitric oxide in the development of severe acute pancreatitis (SAP) and the therapeutic effects of sandostatin (SS) in rats.
METHODS: SAP models were induced by retrograde injection of 15 g/L sodium deoxycholate and then treated by SS. The plasma levels of endotoxin (ET), lipid peroxide (LPO), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and nitric oxide (NO), as well as the expression LPO, TNF-α, IL-6 and NO in pancreatic tissues, were measured. The changes of pancreatic histology were examined under light microscope.
RESULTS: As Compared with those in sham operation group, the plasma levels of ET, LPO, TNF-α, IL-6 and NO were markedly higher in SAP group (P < 0.01), and the changes of ET, LPO, TNF-α and NO at 6 h were higher (898 ± 114 EU/L, 24.58 ± 1.23 μmol/L, 246.3 ± 16.5 ng/L, 162 ......
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