【摘要】 目的 研究2型糖尿病患者中幽门螺杆菌(helicobacter pylori,Hp)感染发生的几率。方法 以2型糖尿病(type 2 diabetes mellitus, T2DM)患者为研究对象，并按有无肾损害将95例男性糖尿病患者分为糖尿病肾病组(diabetic nephropathy，DN)44例及糖尿病非肾病组(non-diabetic nephropathy ，NDN)51例，两组在年龄、病程、血糖控制及药物治疗方面相匹配。另以61例健康男性为对照组，年龄及体重指数(BMI)与研究对象(DM组)相匹配。所有对象均行电子胃镜检查并取胃窦黏膜活检进行幽门螺杆菌检查，并对每日饮酒量进行问卷调查。结果 (1)DN组Hp感染几率明显高于对照组(P<0.01)，而NDN组Hp感染几率与对照组差异无显著性(P>0.05)。(2)与对照组比较，DN组有明显的脂质代谢异常：甘油三酯(TG)及胆固醇(TC)增高；每日饮酒量明显高于对照组(P<0.01)；低密度脂蛋白(LDL)及收缩压显著高于对照组(P<0.05)。结论 T2DM患者Hp感染的发生率与是否合并糖尿病肾损害有关，T2DM合并肾损害者发生Hp感染的几率明显高于正常对照组，而无DN者其Hp感染的发生几率与正常对照组差异无显著性。

    【关键词】 糖尿病；幽门螺杆菌；相关性研究

    Correlative research of diabetes mellitus and Helicobacter pylori infection

    LI Min.Department of Degastive Internal Medicin,Central-South Hospital,Medical College of Wuhan University,Hubei 433121,China

    【Abstract】 Objective The aim of this study was to investigate the prevalence of Helicobacter pylori (Hp) infection in patients with type 2 diabetes mellitus (T2DM). Methods According to whether the presence of kidney damage, 95 patients (males T2DM) were divided into two groups, diabetic nephropathy group(DN,44) and non-diabetic nephropathy group(NDN,51). Age,duration of diabetes, glycemic control and medication matched in two groups. 61age-and BMI-matched healthy people (males) was served as a control group. All people underwent gastroscopy with biopsy specimens being collected from gastric antrum and Hp was evaluated. All subjects completed a daily volume of alcohol consumption questionnaire.Results (1)The prevalence of Hp infection was found to be significantly higher in DN than in controls(P<0.01),while the prevalence of Hp infection was not significant difference between NDN group and control group(P>0.05).(2)DN group was found to be significantly metabolism of lipids disorder: TG and TC were higher in comparison with control group. Daily volume of alcohol consumption , low density lipoprotein(LDL)and systolic pressure(SP) were significantly higher in DN compared to controls(P<0.01 and P<0.05 respectively). Conclusion Prevalence of Hp infection in T2DM is associated with whether the presence of kidney damage. The prevalence of Hp infection in patients with DN was significantly higher than control group, while the prevalence of Hp infection was not significant difference between NDN group and control group. ......