气道炎症_____锌；支气管哮喘；气道炎症

缺锌对哮喘大鼠气道炎症的影响

http://www.100md.com 《咸宁学院学报(医学版)》 2006年第2期

气道炎症,,锌；支气管哮喘；气道炎症,1材料和方法,2结果,3讨论,参考文献：

     摘要：目的探讨缺锌对哮喘大鼠气道炎症的影响。方法 SD大鼠32只，根据体重按随机区组设计分为4组，每组8只。A组为缺锌饲料+卵清蛋白(OVA)激发组；B组为正常锌饲料+ OVA激发组；C组为正常锌饲料配对饲养+ OVA激发组；D组为正常锌饲料+生理盐水激发组。建立缺锌及哮喘模型，诱喘后24h取支气管肺泡灌洗液(BALF)进行细胞分类及右肺中叶HE染色，镜下观察支气管肺组织形态学改变并计数气道壁及BALF中嗜酸粒细胞、中性粒细胞及巨噬细胞数。结果：A、B、C组BALF及支气管管壁中嗜酸粒细胞、中性粒细胞和巨噬细胞数较D组明显增加(P<0.05)。与B组大鼠相比，A组大鼠BALF及支气管管壁中嗜酸粒细胞、中性粒细胞、巨噬细胞数明显增加(P<0.05)，气道炎症反应增加。B组与C组相比，气道炎症反应无明显差异(P>0.05)。结论缺锌时哮喘大鼠气道炎症反应增加,这可能是饮食锌的摄入减少导致哮喘发作增加及症状加重的原因。

    关键词：锌；支气管哮喘；气道炎症

    Effects of Zincdeficiency on the Airway Inflammation in Asthmatic Rats

    CHEN Yuandong，LU Hongyan， LIU Liegang

    (Department of Nutrition and Food Hygiene, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei 430030, China)

    ABSTRACT：Objective To investigate the effects of zincdeficiency on the airway inflammation in asthmatic rats. Methods Thirtytwo SD rats were divided into four groups according to weight: zinc deficient diet add OVA challenge group (group A), zincnormal diet add OVA challenge group (group B),zinc normal pairfed diet add OVA challenge group (group C) and zinc normal diet add saline challenge group (group D). Animal models of asthma and zincdeficiency were established. Twentyfour hours after inducing asthma ......

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