摘要：目的：CT引导下放射性碘125粒子植入组织间近距离治疗脊柱转移瘤的技术可行性、近期疗效及副反应。方法：10例脊柱旁转移癌患者，局部麻醉，术前行CT扫描，层厚5mm，将图象传送到计算机治疗计划系统，行三维治疗计划。治疗靶体积(PTV)为临床靶体积(CTV)外放1mm，粒子活度0.5mci～0.7mci。肿瘤匹配周边剂量为115～145GY。结果：10例患者均成功完成植入术，平均历时3～5h。粒子植入数目为10～88棵。中位粒子数29颗。8例患者疼痛缓解率100%，疼痛完全缓解率89%，肿瘤1年局部控制率70%。无临床相关并发症。结论：经CT引导下放射性粒子碘125组织间近距离治疗脊柱旁转移癌具有微创、安全、并发症发生率低等特点，可以作为姑息治疗脊柱旁转移癌的方法。

    关键词： 碘125； CT引导； 脊柱转移癌

    The Observation of 125I Seeds Implant Treating Spinal Metastatic Carcinoma

    WANG Li-hua, LIU Quan, WANG Cui-ying, et al

    (The Second Hospital of Chifeng, Neimenggu Chifeng 024000, China)

    Abstract： Objective: To observe the feasibility near efficiency and side-effect of adopt 125I radioactivity seeds implant under CT direct. Method: 10 patients with spinal metastatic carcinoma , using local anesthesia. we use CT scan before operation .every section 5mm,then we transmit it to computer theraputic plan system and formulate 3-dimensional radiotheraputic plan.plan tumor volume (PTV) is beyond clinic tumor volume (CTV) 1mm.seeds activity 0.5mci～0.7mci. Tumor matching periphery dosage 10～88 grains and midian seeds number 29 .8 patients complete remission in pain. Remission rate 89% and 1 year tumor control rate 70%.there are no clinical complications. Conclusion： 125I seeds imgration under CT-direct is a short distance-radiotheraputic mean to deal with metastatic carcinoma of spinal.The characteristic is min-trauma、safety、low complication. We can use itpalliate pain of spinal metastatic carcinoma. ......