高血压_____高血压；血管肥厚；左旋精氨酸

L精氨酸对肾性高血压大鼠主动脉肥厚的影响

http://www.100md.com 《咸宁学院学报(医学版)》 2005年第6期

高血压,,高血压；血管肥厚；左旋精氨酸,1材料与方法,2结果,3讨论,参考文献:

     摘要：目的探讨一氧化氮前体L精氨酸对肾血管性高血压大鼠主动脉肥厚的影响。方法采用两肾一夹Glodblatt肾血管性高血压大鼠模型。所有大鼠被随机分为4组(每组10只)：假手术对照组，高血压对照组，L精氨酸治疗组(于术后第5周开始每天给予L精氨酸200mg/kg)，LNAME处理组(于术后第5周开始每天同时给予LNAME 10mg/kg及L精氨酸200mg/kg)。采用标准尾套法间接检测清醒大鼠血压。给药8周后，处死大鼠，分离胸主动脉用于检测主动脉重/体重比、胸主动脉中膜厚度及中膜截面积(应用石蜡切片的彩色图像分析技术)。结果 L精氨酸治疗明显抑制了肾动脉狭窄术后的血压升高，减小了主动脉重/体重比、主动脉中膜厚度及中膜截面积。LNAME明显抑制了L精氨酸的上述作用。结论长疗程L精氨酸治疗在抗高血压的同时也具有抑制主动脉肥厚的作用。

    关键词：高血压；血管肥厚；左旋精氨酸

    The Effects of Larginine on Aortic Hypertrophyin Renovascular Hypertensive Rats

    YU Liangzhu, HUA Changlin, WANG Banghua, et al

    (Department of Physiology, Xianning College, Xianning Hubei 437100 China)

    ABSTRACT: Objective To investigate the role of Larginine, a nitric oxide (NO) precursor, on aortic hypertrophy in renovascular hypertensive rats. Methods The Glodblatt renovascular hypertension model was induced in rats by twokidney one clip method. All the rats were randomly divided into four groups (n=10 per group): ①the shamoperated control group; ②the 2K1C renohypertensive control group; ③the 2K1C+LArg group, the twokidneyoneclip rats were treated with Larginine at a dose of 200mg·kg-1·d-1 from 5th week after renal artery constriction; ④the 2K1C+LNAME group, the twokidneyoneclip rats were treated with LNAME (10 mg·kg-1·d-1) plus Larginine (200mg·kg-1·d-1) from 5th week after renal artery constriction. Indirect blood pressure was measured in conscious rats by the standard tailcuff methods. After treatment with both drugs for 8 weeks, the rats were killed and the thoracic aorta was removed to determine the aorta weight/body weight ratio, media thickness and media crosssectional area of thoracic aorta by an color image analysis system. Results Larginine significantly inhibited the increase of blood pressure, aorta weight/body weight ratio (AW/BW), media thickness and media crosssectional area of thoracic aorta, and these effects of Larginine could be inhibited by LNAME. Conclusion Oral treatment with Larginine inhibit aortic hypertrophy in renovascular hypertensive rats. ......

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