2型糖尿病__(期刊论文)

脂糖舒对2型糖尿病大鼠血浆果糖胺含量和抗氧化酶活性的影响

http://www.100md.com 《咸宁学院学报(医学版)》 2005年第6期

2型糖尿病,,2型糖尿病；脂糖舒；非酶糖化；脂质过氧化,1材料与方法,2结果,3讨论,参考文献：

     摘要：目的探讨脂糖舒对2型糖尿病血清蛋白非酶糖化和脂质过氧化反应的抑制作用。方法采用链脲霉素(30mg/kg)一次性腹腔注射辅以高热量饲料喂养9周制备2型糖尿病大鼠模型，然后分别用等容量生理盐水和不同剂量的脂糖舒灌胃9周，并取健康大鼠作正常对照，测定各组大鼠空腹血浆胰岛素(FIns)和葡萄糖(FBG)及血清果糖胺(FMN)、游离脂肪酸(FFA)、丙二醛(MDA)含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSHPX)和过氧化氢酶(CAT)的活性。计算体重指数(BMI)、胰岛素抵抗指数(IRI)和胰岛素敏感指数(ISI)。结果 ①模型组BMI、IRI、 FIns、FBG、FFA、FMN和MDA显著升高，而ISI、SOD、GSHPX和CAT显著降低(较正常组P<0.01)；②二剂量脂糖舒均能使上述各指标值显著逆转(较模型组P<0.05)；③脂糖舒二组间IRI、ISI和FMN差异显著(P<0.05)。结论脂糖舒对2型糖尿病模型大鼠不仅有明显降糖降脂、改善胰岛素抵抗和胰岛素敏感性作用，而且对其血浆蛋白非酶糖化和脂质过氧化亦有显著的抑制作用。

    关键词：2型糖尿病；脂糖舒；非酶糖化；脂质过氧化

    Effects of Zhitangshu on the Contents of Fructosamine and the Activities of Antioxidases

    in Serum of the Rats with Type2diabetes

    SHU Sijie，WU Jilian，SHU Hui，et al

    (Department of Pharmacy ，Xianning College, Xianning Hubei 437100 , China)

    ABSTRACT： Objective To explore the inhibiting effects of Zhitangshu (ZTS) on nonenzyme glycosylation of serum protein and on peroxide of lipid in serum of the rats with type2diabetes. Methods The model of rats with type2diabeties mellitus was established by using the low dose of streptozotocin (30mg/kg) and highcaloric feeding . The same amount of normal saline and the different does of ZTS were perfused into the stomach of these rats once a day for 9 weeks . The healthy rats were chosen to constitute the control group. The contents of insulin (Ins) , glucose (Glu) , free fatty acid (FFA) fruetosamine (FMN) and malondialdehyde (MDA) and the activities of superoxide dismutase (SOD) , glutathione peroxidase (GSHPX) and catalase (CAT) in serum were determined and bodyweigh index (BMI) , insulin resistance index (IRI) and insulin sensitivity index (ISI) were calculated . Results①he BMI , IRI and the contents of FMN , FFA , FIns , FBG and MDA were obviously increased while ISI and the activities of SOD , GSHPX and CAT markedly decreased in serum of the diabetic rats’ model (P<0.01 , compared with control group) . ②Both dosage of ZTS could reverse all above indexes (P<0.05).③There were remarkable differences of IRI,ISI and FMN between the two dosage ZTS group(P<0.05). Conclusion ZTS has remarkable effect of lowering the insulin resistance and inhibiting the nonenzyme glycosylation of serum protein and the lipidperoxidation in type2diabetes rats . ......

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