[摘 要] 目的:通过观察小檗碱对球囊损伤后兔颈动脉内膜增生与血管重塑的影响，为血管成形术后再狭窄的防治寻找新的治疗策略。方法:日本大耳白兔40只，随机分为假手术组、模型组、小檗碱组和辛伐他汀组，除假手术组外各组均以球囊导管扩张损伤颈动脉内膜，并分别给予生理盐水、小檗碱和辛伐他汀各2.5 mg /(kg·d)腹腔注射，假手术组仅普食喂养。术后15 d取损伤颈动脉段切片，作形态学观察，利用图像分析系统测量血管新生内膜厚度(IT)、管腔面积(LA)、新生内膜面积(IA)、内弹力板围绕面积(IEL)、中膜面积(MA)、外弹力板围绕面积(EEL)。结果:血管球囊损伤后, 小檗碱组和辛伐他汀组IT、IA、IA/MA均显著小于模型组(P<0.01)。与模型组相比，小檗碱组和辛伐他汀组LA、IEL、EEL均显著增大(P<0.01), MA则无显著性差异。结论:小檗碱可通过抑制兔颈动脉新生内膜增生与不良的血管重塑, 从而为小檗碱防治血管成形术后再狭窄提供了实验基础。

    [关键词] 球囊损伤；内膜增生；血管重塑；再狭窄；小檗碱；兔

    Effect of berberine on Restenosis after Percutaneous Transluminal Angioplasty of carotid artery in rabbits

    Zhang Huan-xin, Zhang Hong-kao, Wang Jian-ning, et al.

    (Department of Cardiology, Renmin Hospital, Yunyang Medical College, Shiyan, Hubei Province 442000, China)

    Abstract:Objective To investigate the effect of berberine on intima hyperplasia and vascular remodeling after balloon withdrawal injury of Rabbit Carotid Artery and explore a novel therapeutic strategy for the prevention of restenosis after percutaneous transluminal angioplasty.Methods Fourty Japanese rabbits were allocated randomly into 4 groups: sham operation group(n=7), model group(n=11) ......