新型促渗剂壬代环戊双醚对双氯芬酸钠凝胶透皮吸收的影晌
壬代环戊双醚,,壬代环戊双醚；双氯芬酸钠凝胶；透皮吸收；新辅料,1试剂、仪器与实验动物,2实验方法,3结果,4讨论,参考文献:
摘要:目的 探讨不同浓度新型促渗剂壬代环戊双醚对双氯芬酸钠凝胶的透皮吸收影响。方法 采用改良Frans扩散池进行体外透皮吸收实验。流动相：甲醇乙酸水溶液(pH=3.0)(体积比70∶30)，紫外检测波长284 nm。结果 壬代环戊双醚含量在2.0%时透皮吸收最好。结论 壬代环戊双醚具有较好的促渗作用，是较好的新型促渗剂。关键词:壬代环戊双醚；双氯芬酸钠凝胶；透皮吸收；新辅料
In vitro evaluation of the effect of 2nonyl1,3dioxolane on percutaneous absorption of diclofenac gel
SHA Mei，YIN Lifang ，XU Wei
(1.Department of Pharmacy,College of Fujian Traditional Chinese Medicine,Fuzhou 350003,China； 2.Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China)Abstract: Objective To evaluate the effect of 2nonyl1,3dioxolane,a penetration enhancer,on in vitro permeation of diclofenac gel.Method The in vitro skin permeation experiment was conducted by using modified Franz diffusion cell. Acetate solution (pH3.0)methanol (70∶30) was used as mobile phase and the detection wavelength was set at 284 nm. Result and Conclusion The optimal concentration of 2nonyl1,3dioxolane for higher percutaneous absorption of diclofenac gel was 2.0%,suggesting that 2nonyl1,3dioxolane is a potent penetration enhancer. ......
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