Correlation between the level of glycosylated hemoglobin A1c and the extent of coronary lesions in patients with coronary heart disease

    FAN Quan, GUO Wenª²Yi, JIA Guoª²Liang

    Department of Cardiovasology,Xijing Hospital,Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To explore the correlation between the level of glycosylated hemoglobin A1c (HbA1c) and the extent of coronary lesions in coronary heart disease (CHD). METHODS: Ninetyª²seven CHD patients were included in the study: simple CHD group (n=32), CHD accompanied with impaired glucose tolerance (IGT) group (n=31) and CHD accompanied with type 2 diabetes mellitus (T2DM) group (n=34).The levels of HbA1c of all the patients were analyzed by radio immunoassay. All the patients underwent coronary angiography and the extent of coronary lesions was analyzed by total amount of coronary narrow degree integral. ERSULTS: The levels of HbA1c and coronary artery narrow degree in CHD accompanied with T2DM group were significantly higher than those of simple CHD group and CHD accompanied with IGT group (P<0.05);those of CHD accompanied with IGT group were significantly higher than those of simple CHD group (P<0.05);correlation analysis showed that the level of HbA1c was positively correlated with the coronary artery narrow degree in CHD patients (r=0.6447, P<0.01). CONCLUSION: The level of HbA1c was positively correlated with the coronary artery narrow degree in CHD patients. The higher level of HbA1c was the independent dangerous factor for CHD. ......